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1

Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality?

Pelkonen, Olavi, Xu, Qihe, Fan, Tai-Ping

Journal:

Journal of Traditional and Complementary Medicine

Year:

2014

Language:

english

File:

PDF, 547 KB

english, 2014

2

Thujone and thujone-containing herbal medicinal and botanical products: Toxicological assessment

Pelkonen, Olavi, Abass, Khaled, Wiesner, Jacqueline

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 921 KB

english, 2013

3

Hepatocytes: The powerhouse of biotransformation

Danielle K. Sevior, Olavi Pelkonen, Jorma T. Ahokas

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2012

Language:

english

File:

PDF, 611 KB

english, 2012

4

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

Moustapha Ouedraogo, Thomas Baudoux, Caroline Stévigny, Joëlle Nortier, Jean-Marie Colet, Thomas Efferth, Fan Qu, Jue Zhou, Kelvin Chan, Debbie Shaw, Olavi Pelkonen, Pierre Duez

Journal:

Journal of Ethnopharmacology

Year:

2012

Language:

english

File:

PDF, 1.20 MB

english, 2012

5

Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver

Eivor Elovaara, Jouni Mikkola, Helene Stockmann-Juvala, Leena Luukkanen, Helena Keski-Hynnilä, Risto Kostiainen, Markku Pasanen, Olavi Pelkonen, Harri Vainio

Journal:

Archives of Toxicology

Year:

2007

Language:

english

File:

PDF, 536 KB

english, 2007

6

Effect of physicochemical and pharmacokinetic properties of barbiturates on the induction of drug metabolism

Olavi Pelkonen, Niilo T. Kärki

Journal:

Chemico-Biological Interactions

Year:

1973

Language:

english

File:

PDF, 409 KB

english, 1973

7

Expression of CYP2A genes in human liver and extrahepatic tissues

Satu Koskela, Jukka Hakkola, Janne Hukkanen, Olavi Pelkonen, Martti Sorri, Antti Saranen, Sisko Anttila, Pedro Fernandez-Salguero, Frank Gonzalez, Hannu Raunio

Journal:

Biochemical Pharmacology

Year:

1999

Language:

english

File:

PDF, 260 KB

english, 1999

8

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

Jukka Hakkola, Markku Pasanen, Raija Purkunen, Seppo Saarikoski, Olavi Pelkonen, Jukka Mäenpää, Anders Rane, Hannu Raunio

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 624 KB

english, 1994

9

Omics and its potential impact on R&D and regulation of complex herbal products

Olavi Pelkonen, Markku Pasanen, John C. Lindon, Kelvin Chan, Liping Zhao, Greer Deal, Qihe Xu, Tai-Ping Fan

Journal:

Journal of Ethnopharmacology

Year:

2012

Language:

english

File:

PDF, 304 KB

english, 2012

10

Treatment of alcoholic cirrhosis with enzyme inducers

Rautio, Arja, Sotaniemi, Eero A, Olavi Pelkonen, R, Luoma, Pauli V

Journal:

Clinical Pharmacology & Therapeutics

Year:

1980

Language:

english

File:

PDF, 569 KB

english, 1980

11

Expression and Regulation of Xenobiotic-Metabolizing Cytochrome P450 (CYP) Enzymes in Human Lung

Hukkanen, Janne, Pelkonen, Olavi, Hakkola, Jukka, Raunio, Hannu

Journal:

Critical Reviews in Toxicology

Year:

2002

Language:

english

File:

PDF, 262 KB

english, 2002

12

The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver

Mäenpää, Jukka, Pelkonen, Olavi, Cresteil, Thierry, Rane, Anders

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

1993

Language:

english

File:

PDF, 680 KB

english, 1993

13

Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

Barter, Zoe, Bayliss, Martin, Beaune, Philip, Boobis, Alan, Carlile, David, Edwards, Robert, Brian Houston, J., Lake, Brian, Lipscomb, John, Pelkonen, Olavi, Tucke, Geoffrey, Rostami-Hodjegan, Amin

Journal:

Current Drug Metabolism

Year:

2007

Language:

english

File:

PDF, 850 KB

english, 2007

14

Cardiac safety of ophthalmic timolol

Mäenpää, Jukka, Pelkonen, Olavi

Journal:

Expert Opinion on Drug Safety

Year:

2016

Language:

english

File:

PDF, 992 KB

english, 2016

15

Toxicology of Herbal Products || Composition and Quality Control of Herbal Medicines

Pelkonen, Olavi, Duez, Pierre, Vuorela, Pia Maarit, Vuorela, Heikki

Year:

2017

Language:

english

File:

PDF, 645 KB

english, 2017

16

Toxicology of Herbal Products || Cardiovascular Toxicities of Herbal Products: An Overview of Selected Compounds

Pelkonen, Olavi, Duez, Pierre, Vuorela, Pia Maarit, Vuorela, Heikki

Year:

2017

Language:

english

File:

PDF, 567 KB

english, 2017

17

Toxicology of Herbal Products || Toxicity of Herbal Medicines: From Past to Present to Future

Pelkonen, Olavi, Duez, Pierre, Vuorela, Pia Maarit, Vuorela, Heikki

Year:

2017

Language:

english

File:

PDF, 192 KB

english, 2017

18

Toxicology of Herbal Products || Toxicokinetics of Herbal Products

Pelkonen, Olavi, Duez, Pierre, Vuorela, Pia Maarit, Vuorela, Heikki

Year:

2017

Language:

english

File:

PDF, 314 KB

english, 2017

19

Toxicology of Herbal Products || Herbal Hepatotoxicity

Pelkonen, Olavi, Duez, Pierre, Vuorela, Pia Maarit, Vuorela, Heikki

Year:

2017

Language:

english

File:

PDF, 431 KB

english, 2017

20

CYP-associated drugâdrug interactions: A mission accomplished?

Pelkonen, Olavi, Hakkola, Jukka, Hukkanen, Janne, Turpeinen, Miia

Journal:

Archives of Toxicology

Year:

2020

File:

PDF, 434 KB

2020

21

Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes

Janne Hukkanen, Jukka Hakkola, Sisko Anttila, Ritva Piipari, Antti Karjalainen, Olavi Pelkonen, Hannu Raunio

Journal:

Molecular Carcinogenesis

Year:

1997

Language:

english

File:

PDF, 164 KB

english, 1997

22

Significant interspecies differences in induction profiles of hepatic CYP enzymes by TCDD in bank and field voles

Mari Murtomaa-Hautala, Merja Korkalainen, Olavi Pelkonen, Nagabhooshan Hegde, Raimo Pohjanvirta, Otso Huitu, Heikki Henttonen, Arja Rautio, Pirkko Viitala, Matti Viluksela

Journal:

Environmental Toxicology and Chemistry

Year:

2012

Language:

english

File:

PDF, 417 KB

english, 2012

23

Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma

Hannu Raunio, Risto Juvonen, Markku Pasanen, Olavi Pelkonen, Paavo Pääkkö, Ylermi Soini

Journal:

Year:

1998

Language:

english

File:

PDF, 144 KB

english, 1998

24

Aryl hydrocarbon hydroxylase in lymphocytes and lung tissue from lung cancer patients and controls

Niilo T. Kärki, Risto Pokela, Lauri Nuutinen, Olavi Pelkonen

Journal:

International Journal of Cancer

Year:

1987

Language:

english

File:

PDF, 652 KB

english, 1987

25

Comparison of the formation of benzo[a]pyrene diolepoxide-dna adducts in vitro by rat and human microsomes: Evidence for the involvement of p-450IA1 and p-450IA2

Dr Kirsi Vähäkangas, Hannu Raunio, Markku Pasamen, Päivi Sivonen, Sang-Shin Park, Harry V. Gelboin, Olavi Pelkonen

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1989

Language:

english

File:

PDF, 632 KB

english, 1989

26

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

Ari Tolonen, Aleksanteri Petsalo, Miia Turpeinen, Jouko Uusitalo, Olavi Pelkonen

Journal:

Journal of Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 510 KB

english, 2007

27

Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P-450-dependent monooxygenase activities

Markku Pasanen, Tapio Haaparanta, Maria Sundin, Paivi Sivonen, Kirsi Vakakangas, Hannu Raunio, Ronald Hines, Jan-Åk Gustafsson, Olavi Pelkonen

Journal:

Year:

1990

Language:

english

File:

PDF, 883 KB

english, 1990

28

The cerium-induced liver injury and oxidative frug metabolism in DBA/2 and C57BL/6 mice

Penti Arvela, Holger Kraul, Frej Stenbäck, Olavi Pelkonen

Journal:

Year:

1991

Language:

english

File:

PDF, 693 KB

english, 1991

29

HPLC method for rapid determination of acetylator phenotype by measuring urinary caffeine metabolites

Imre Klebovich, Pentti Arvela, Olavi Pelkonen

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

1993

Language:

english

File:

PDF, 452 KB

english, 1993

30

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography–tandem mass spectrometry utilizing sub 2 μm particle size column

Aleksanteri Petsalo, Miia Turpeinen, Olavi Pelkonen, Ari Tolonen

Journal:

Journal of Chromatography A

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

31

Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions*

Sotaniemi, Eero A., Arranto, Arno J., Pelkonen, Olavi, Pasanen, Markku

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 904 KB

english, 1997

32

CYP2D6 polymorphism is not crucial for the disposition of selegiline*

Scheinin, Harry, Anttila, Markku, Dahl, Marja-Liisa, Karnani, Hari, Nyman, Leena, Taavitsainen, Päivi, Pelkonen, Olavi, Bertilsson, Leif

Journal:

Clinical Pharmacology & Therapeutics

Year:

1998

Language:

english

File:

PDF, 947 KB

english, 1998

33

Hepatitis A impairs the function of human hepatic CYP2A6 in vivo

Markku Pasanen, Zoja Rannala, Aivar Tooming, Eero A Sotaniemi, Olavi Pelkonen, Arja Rautio

Journal:

Year:

1997

Language:

english

File:

PDF, 144 KB

english, 1997

34

CYP2A6: a human coumarin 7-hydroxylase

Olavi Pelkonen, Arja Rautio, Hannu Raunio, Markku Pasanen

Journal:

Year:

2000

Language:

english

File:

PDF, 85 KB

english, 2000

35

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes

Päivi Taavitsainen, Markku Anttila, Leena Nyman, Hari Karnani, Jarmo S. Salonen, Olavi Pelkonen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2000

Language:

english

File:

PDF, 101 KB

english, 2000

36

Diabetes and Elimination of Antipyrine in Man: An Analysis of 298 Patients Classified by Type of Diabetes, Age, Sex, Duration of Disease and Liver Involvement

Eero A. Sotaniemi, Olavi Pelkonen, Arno J. Arranto, Päivi Tapanainen, Arja Rautio, Markku Pasanen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2002

Language:

english

File:

PDF, 116 KB

english, 2002

37

Polymorphisms of CYP2A6 and its practical consequences

Hannu Raunio, Arja Rautio, Harriet Gullstén, Olavi Pelkonen

Journal:

British Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 128 KB

english, 2001

38

Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry

Timo Rousu, Olavi Pelkonen, Ari Tolonen

Journal:

Rapid Communications in Mass Spectrometry

Year:

2009

Language:

english

File:

PDF, 196 KB

english, 2009

39

Relationship between lipid composition and drug metabolizing capacity of human liver

M. J. Savolainen, A. J. Arranto, I. E. Hassinen, P. V. Luoma, R. Olavi Pelkonen, E. A. Sotaniemi

Journal:

European Journal of Clinical Pharmacology

Year:

1985

Language:

english

File:

PDF, 698 KB

english, 1985

40

Regulation of CYP2A5 induction by porphyrinogenic agents in mouse primary hepatocytes

P. Salonpää, Sami Kottari, Olavi Pelkonen, Hannu Raunio

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1996

Language:

english

File:

PDF, 239 KB

english, 1996

41

Inhibition and induction of human cytochrome P450 enzymes: current status

Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen, Hannu Raunio

Journal:

Archives of Toxicology

Year:

2008

Language:

english

File:

PDF, 790 KB

english, 2008

42

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

Sarah Adler, David Basketter, Stuart Creton, Olavi Pelkonen, Jan van Benthem, Valérie Zuang, Klaus Ejner Andersen, Alexandre Angers-Loustau, Aynur Aptula, Anna Bal-Price, Emilio Benfenati, Ulrike Bern

Journal:

Archives of Toxicology

Year:

2011

Language:

english

File:

PDF, 1.59 MB

english, 2011

43

The role of CYP enzymes in cocaine-induced liver damage

Markku Pasanen, Pertti Pellinen, Frej Stenbäck, Risto O. Juvonen, Hannu Raunio, Olavi Pelkonen

Journal:

Archives of Toxicology

Year:

1995

Language:

english

File:

PDF, 408 KB

english, 1995

44

Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes

Anneli Kojo, Pirkko Viitala, Markku Pasanen, Olavi Pelkonen, Hannu Raunio, Risto Juvonen

Journal:

Archives of Toxicology

Year:

1998

Language:

english

File:

PDF, 326 KB

english, 1998

45

Cytochromes P450, induction and cholesterol—what are the connections?

Olavi Pelkonen, Jukka Hakkola

Journal:

European Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 68 KB

english, 2008

46

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

Timo Korjamo, Jukka Mönkkönen, Jouko Uusitalo, Miia Turpeinen, Olavi Pelkonen, Paavo Honkakoski

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 439 KB

english, 2006

47

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites

Miia Turpeinen, Niina Koivuviita, Ari Tolonen, Petri Reponen, Stefan Lundgren, Jouko Miettunen, Kaj Metsärinne, Anders Rane, Olavi Pelkonen, Kari Laine

Journal:

British Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 162 KB

english, 2007

48

Expression of Cytochrome P450 Genes Encoding Enzymes Active in the Metabolism of Tamoxifen in Human Uterine Endometrium

Janne Hukkanen, Marjatta Mantyla, Lauri Kangas, Pauli Wirta, Jukka Hakkola, Pauliina Paakki, Sari Evisalmi, Olavi Pelkonen, Hannu Raunio

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1998

Language:

english

File:

PDF, 527 KB

english, 1998

49

Cytochrome P450 Specificity of Metabolism and Interactions of Oxybutynin in Human Liver Microsomes

Eeva Lukkari, Päivi Taavitsainen, Auni Juhakoskr, Olavi Pelkonen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1998

Language:

english

File:

PDF, 607 KB

english, 1998

50

Developmental Expression of Cytochrome P450 Enzymes in Human Liver

Jukka Hakkola, Einosuke Tanaka, Olavi Pelkonen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1998

Language:

english

File:

PDF, 955 KB

english, 1998

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